Presently, there is no cure for Rett syndrome.

Treatment focusses on management of symptoms and can include medications for seizures, reflux, breathing problems and mood, and therapies aimed at improving movement and function. The latter include physical and occupational therapy, music therapy, sensory integration, speech therapy, hydrotherapy and horseback riding.

Surgery may be required to remedy curvature of the spine, foot deformities, swallowing difficulties or reflux.